Pathogenesis, evaluation and pathogenetic therapy of diabetic polyneuropathy

The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines high prevalence late complications diabetes, including diabetic polyneuropathy (DPN), most common type polyneuropathy. Oxidative stress is considered main reason for cellular pathology development mellitus, which use antioxidants DPN treatment. Alpha-lipoic acid (ALA), a natural fat-soluble antioxidant, effective drug reducing symptoms. Furthermore, symptom-modifying effect ALA has been shown numerous randomized controlled trials. article discusses possible disease-modifying ALA.